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On the following day, of the media was changed and SMAD inhibition was initiated by the addition of 10 M SB-431542

Serum samples were analyzed for liver function markers (Alanine transferase/ALT, Aspartate transferase/AST), renal function markers (Urea nitrogen, Creatinine/Cr), and myocardial enzyme indexes (Creatine Kinase/CK, Creatine Kinase-MB/CK-MB, Lactate Dehydrogenase-L/LDH-L)

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It may help lighten pigmentation but does not treat acne scars structurally